Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Extracellular Matrix Remodeling during Left Ventricular Diastolic Dysfunction and Heart Failure with Preserved Ejection Fraction: A Systematic Review and Meta-Analysis

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are pivotal regulators of extracellular matrix (ECM) composition and could, due to their dynamic activity, function as prognostic tools for fibrosis and cardiac function in left ventricular diastolic dysfunction (LV...

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Bibliographic Details
Main Authors: Merle M. Krebber, Christian G. M. van Dijk, Robin W. M. Vernooij, Maarten M. Brandt, Craig A. Emter, Christoph D. Rau, Joost O. Fledderus, Dirk J. Duncker, Marianne C. Verhaar, Caroline Cheng, Jaap A. Joles
Format: Artigo
Language:Inglês
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
heart failure with preserved ejection fraction
left ventricular diastolic dysfunction
extracellular matrix
fibrosis
matrix metalloproteinase
tissue inhibitor of metalloproteinase
Online Access:https://www.mdpi.com/1422-0067/21/18/6742
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