A novel CD147 inhibitor, SP-8356, reduces neointimal hyperplasia and arterial stiffness in a rat model of partial carotid artery ligation

Abstract Background Neointimal hyperplasia and its related arterial stiffness are the crucial pathophysiological features in atherosclerosis and in-stent restenosis. Cluster of differentiation 147 (CD147), a member of the immunoglobulin super family that induces the expression of matrix metalloprote...

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Main Authors: Kisoo Pahk, Hyojin Noh, Chanmin Joung, Mi Jang, Hwa Young Song, Kyung Won Kim, Kihoon Han, Jong-Ik Hwang, Sungeun Kim, Won-Ki Kim
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-08-01
Colecção:Journal of Translational Medicine
Assuntos:
Atherosclerosis
Neointimal hyperplasia
Arterial stiffness
Vascular smooth muscle cell
CD147
Matrix metalloproteinase
Acesso em linha:http://link.springer.com/article/10.1186/s12967-019-2024-y
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