The Absence of NLRP3-inflammasome Modulates Hepatic Fibrosis Progression, Lipid Metabolism, and Inflammation in KO NLRP3 Mice during Aging

Aging is associated with metabolic changes and low-grade inflammation in several organs, which may be due to NLRP3 inflammasome activation. Methods: Here, we asked whether age-related liver changes such as lipid metabolism and fibrosis are reduced in aged mice lacking the NLRP3 inflammasome. We repo...

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Hlavní autoři: Paloma Gallego, Beatriz Castejón-Vega, José A. del Campo, Mario D. Cordero
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2020-09-01
Edice:Cells
Témata:
non-alcoholic fatty liver disease
oxidative stress
liver damage
inflammation
NLRP3-inflammasome complex
On-line přístup:https://www.mdpi.com/2073-4409/9/10/2148
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