Optimization and in-vivo evaluation of isradipine nanoparticles using Box-Behnken design surface response methodology

The isradipine is the potent anti hypertensive drug, which is matrix in polymeric nanoparticle by using solvent evaporation method. In this work, 3-factor, 3-level Box-Behnken design was used to optimize the process parameters like polymer concentration (A), sonication frequency (B) and sonication t...

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Autori principali: Vijayan Venugopal, K. Jayaraja Kumar, S. Muralidharan, S. Parasuraman, P. Vasanth Raj, K. Venkates Kumar
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2016-01-01
Serie:OpenNano
Soggetti:
Isradipine
Nanoparticle
Surface response
Box-Behnken design
In-vivo studies
Accesso online:http://www.sciencedirect.com/science/article/pii/S2352952015300086
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