Cathelicidin Contributes to the Restriction of Leishmania in Human Host Macrophages

In cutaneous Leishmaniasis the parasitic control in human host macrophages is still poorly understood. We found an increased expression of the human cathelicidin CAMP in skin lesions of Ethiopian patients with cutaneous leishmaniasis. Vitamin D driven, Cathelicidin-type antimicrobial peptides (CAMP)...

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Detalhes bibliográficos
Main Authors: Peter Crauwels, Elena Bank, Bianca Walber, Ulf Alexander Wenzel, Birgitta Agerberth, Menberework Chanyalew, Markos Abebe, Renate König, Uwe Ritter, Norbert Reiling, Ger van Zandbergen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-11-01
Colecção:Frontiers in Immunology
Assuntos:
Leishmania
human macrophages
vitamin D
cathelicidin (LL-37)
human primary immune cells
antimicrobial activity
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2019.02697/full
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