Quantitative Evaluation of the Transcriptional Activity of Steroid Hormone Receptor Mutants and Variants Using a Single Vector With Two Reporters and a Receptor Expression Cassette

Although the rapid development of high-throughput sequencing has led to the identification of a large number of truncated or mutated steroid hormone receptor (SHR) variants, their clinical relevance remains to be defined. A platform for functional analysis of these SHR variants in cells would be ins...

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Main Authors: Huimin Ji, Ying Li, Zhao Liu, Min Tang, Lihui Zou, Fei Su, Yaqun Zhang, Junhua Zhang, Hexin Li, Lin Li, Bin Ai, Jie Ma, Lunan Wang, Ming Liu, Fei Xiao
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Endocrinology
Assuntos:
steroid hormone receptors (SHRs)
mutations
splicing variations
dual-luciferase reporter assay
transactivation activity
Acceso en liña:https://www.frontiersin.org/article/10.3389/fendo.2020.00167/full
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