Extracellular matrix fragmentation in young, healthy cartilaginous tissues

Although the composition and structure of cartilaginous tissues is complex, collagen II fibrils and aggrecan are the most abundant assemblies in both articular cartilage (AC) and the nucleus pulposus (NP) of the intervertebral disc (IVD). Whilst structural heterogeneity of intact aggrecan ( containi...

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Bibliographic Details
Main Authors: RJ Craddock, NW Hodson, M Ozols, T Shearer, JA Hoyland, MJ Sherratt
Format: Artigo
Language:Inglês
Published: AO Research Institute Davos 2018-02-01
Series:European Cells & Materials
Subjects:
Cartilage
intervertebral disc
extracellular matrix
aggrecan
glycosaminoglycans
protein structure
protein homeostasis
nanomechanics
structural biology
Online Access:http://www.ecmjournal.org/papers/vol035/pdf/v035a04.pdf
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