PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange during Spermiogenesis

Summary: Spermatogenesis is a complex process of sperm generation, including mitosis, meiosis, and spermiogenesis. During spermiogenesis, histones in post-meiotic spermatids are removed from chromatin and replaced by protamines. Although histone-to-protamine exchange is important for sperm nuclear c...

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Main Authors: Chang Rok Kim, Taichi Noda, Hyunkyung Kim, Gibeom Kim, Seongwan Park, Yongwoo Na, Seiya Oura, Keisuke Shimada, Injin Bang, Jun-Yeong Ahn, Yong Ryoul Kim, Se Kyu Oh, Hee-Jung Choi, Jong-Seo Kim, Inkyung Jung, Ho Lee, Yuki Okada, Masahito Ikawa, Sung Hee Baek
Formáid: Artigo
Teanga:Inglês
Foilsithe: Elsevier 2020-07-01
Sraith:Cell Reports
Ábhair:
PHF7
histone-to-protamine exchange
H3K14ub
H4 hyperacetylation
histone removal
BRDT
Rochtain Ar Líne:http://www.sciencedirect.com/science/article/pii/S2211124720309311
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