Multi-omic rejuvenation of human cells by maturation phase transient reprogramming

Ageing is the gradual decline in organismal fitness that occurs over time leading to tissue dysfunction and disease. At the cellular level, ageing is associated with reduced function, altered gene expression and a perturbed epigenome. Recent work has demonstrated that the epigenome is already rejuve...

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Bibliographic Details
Main Authors: Diljeet Gill, Aled Parry, Fátima Santos, Hanneke Okkenhaug, Christopher D Todd, Irene Hernando-Herraez, Thomas M Stubbs, Inês Milagre, Wolf Reik
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications Ltd 2022-04-01
Series:eLife
Subjects:
ageing
reprogramming
DNA methylation
transcription
rejuvenation
Online Access:https://elifesciences.org/articles/71624
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