Structure-Based Virtual Screening, Synthesis and Biological Evaluation of Potential FAK-FAT Domain Inhibitors for Treatment of Metastatic Cancer

Focal adhesion kinase (FAK) is a tyrosine kinase that is overexpressed and activated in several advanced-stage solid cancers. In cancer cells, FAK promotes the progression and metastasis of tumours. In this study, we used structure-based virtual screening to filter a library of more than 210K compou...

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Bibliografiske detaljer
Main Authors: Sahar B. Kandil, Samuel R. Jones, Sonia Smith, Stephen E. Hiscox, Andrew D. Westwell
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2020-07-01
Serier:Molecules
Fag:
focal adhesion kinase (FAK)
breast cancer (BC)
pancreatic cancer
triple negative breast cancer (TNBC)
chloropyramine (C4)
rational drug design
Online adgang:https://www.mdpi.com/1420-3049/25/15/3488
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