Deficiency of Thyroid Hormone Reduces Voltage-Gated Na<sup>+</sup> Currents as Well as Expression of Na<sup>+</sup>/K<sup>+</sup>-ATPase in the Mouse Hippocampus

Mice lacking functional thyroid follicular cells, <i>Pax8<sup>−/−</sup></i> mice, die early postnatally, making them suitable models for extreme hypothyroidism. We have previously obtained evidence in postnatal rat neurons, that a down-regulation of Na<sup>+</sup>...

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Hauptverfasser: Sivaraj Mohana Sundaram, Romy Marx, Heiko M. Lesslich, Irmgard D. Dietzel
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2022-04-01
Schriftenreihe:International Journal of Molecular Sciences
Schlagworte:
thyroid hormone
congenital hypothyroidism
hippocampal neurons
Na<sup>+</sup> current density
Na<sup>+</sup>/K<sup>+</sup>-ATPase
mouse brain
Online Zugang:https://www.mdpi.com/1422-0067/23/8/4133
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