Palmitoylethanolamide treatment reduces blood pressure in spontaneously hypertensive rats: involvement of cytochrome p450-derived eicosanoids and renin angiotensin system.

Palmitoylethanolamide (PEA), a peroxisome proliferator-activated receptor-α agonist, has been demonstrated to reduce blood pressure and kidney damage secondary to hypertension in spontaneously hypertensive rat (SHR). Currently, no information is available concerning the putative effect of PEA on mod...

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Main Authors: Giuseppina Mattace Raso, Claudio Pirozzi, Roberta d'Emmanuele di Villa Bianca, Raffaele Simeoli, Anna Santoro, Adriano Lama, Francesca Di Guida, Roberto Russo, Carmen De Caro, Raffaella Sorrentino, Antonio Calignano, Rosaria Meli
Format: Artigo
Language:Inglês
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4423982?pdf=render
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