The Estradiol Synthesis Inhibitor Formestane Diminishes the Ability of Sevoflurane to Induce Neurodevelopmental Abnormalities in Male Rats

BackgroundIn rodents, the period of increased vulnerability to the developmental effects of general anesthetics coincides with the period of age-specific organizing (masculinizing) effects of the major female sex hormone 17β-estradiol (E2) in the male brain and excitatory GABA type A receptor (GABAA...

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Main Authors: Jie Wang, Baofeng Yang, Lingsha Ju, Jiaojiao Yang, Andrea Allen, Jiaqiang Zhang, Anatoly E. Martynyuk
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Systems Neuroscience
Assuntos:
sevoflurane
EEG seizures
behavioral abnormalities
corticosterone
estradiol
excitatory GABAA receptor signaling
Acceso en liña:https://www.frontiersin.org/article/10.3389/fnsys.2020.546531/full
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