Heterogeneity of Mismatch Repair Status and Microsatellite Instability between Primary Tumour and Metastasis and Its Implications for Immunotherapy in Colorectal Cancers

Deficient mismatch repair system (dMMR)/microsatellite instability (MSI) is found in about 5% of metastatic colorectal cancers (mCRCs) with a major therapeutic impact for immune checkpoint inhibitor (ICI) use. We conducted a multicentre study including all consecutive patients with a dMMR/MSI mCRC....

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Camille Evrard, Stéphane Messina, David Sefrioui, Éric Frouin, Marie-Luce Auriault, Romain Chautard, Aziz Zaanan, Marion Jaffrelot, Christelle De La Fouchardière, Thomas Aparicio, Romain Coriat, Julie Godet, Christine Silvain, Violaine Randrian, Jean-Christophe Sabourin, Rosine Guimbaud, Elodie Miquelestorena-Standley, Thierry Lecomte, Valérie Moulin, Lucie Karayan-Tapon, Gaëlle Tachon, David Tougeron
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: MDPI AG 2022-04-01
Σειρά:International Journal of Molecular Sciences
Θέματα:
colorectal cancer
microsatellite instability
deficient mismatch repair
immunohistochemistry
inter-tumoral heterogeneity
Διαθέσιμο Online:https://www.mdpi.com/1422-0067/23/8/4427
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