The Chronic Stages of Bovine Fasciola hepatica Are Dominated by CD4 T-Cell Exhaustion

Fasciola hepatica infection of ruminants leads to non-resolving chronic infection, as patency develops, there is switching to a TGF-β and IL-10 led response. Here, we explore the responses of CD4 T-cells within the major draining lymph nodes. We found minimal expression of Foxp3 within CD4 cells but...

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Autors principals:	Divya Sachdev, Kevin C. Gough, Robin J. Flynn
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2017-08-01
Col·lecció:	Frontiers in Immunology
Matèries:	Fasciola hepatica chronic helminth infection T-cell responses IL-10 IL-2 hyporesponsive
Accés en línia:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.01002/full
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