Nanoparticle System Based on Amino-Dextran as a Drug Delivery Vehicle: Immune-Stimulatory CpG-Oligonucleotide Loading and Delivery

The aim of this study is to prepare and characterize an amino-dextran nanoparticle (aDNP) platform and investigate two loading strategies for unmethylated cytosine-phosphate-guanine (CpG) oligonucleotide. aDNP was prepared by desolvation of amino-dextran followed by the chemical crosslinking of amin...

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Detalhes bibliográficos

Principais autores:	Hien V. Nguyen, Katrin Campbell, Gavin F. Painter, Sarah L. Young, Greg F. Walker
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2020-11-01
coleção:	Pharmaceutics
Assuntos:	dextran nanoparticle desolvation vaccine formulation CpG oligonucleotide CpG adsorption CpG conjugation
Acesso em linha:	https://www.mdpi.com/1999-4923/12/12/1150
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