Synthesis and Evaluation of the Antidepressant-like Properties of HBK-10, a Novel 2-Methoxyphenylpiperazine Derivative Targeting the 5-HT_1A and D₂ Receptors

The increasing number of patients reporting depressive symptoms requires the design of new antidepressants with higher efficacy and limited side effects. As our previous research showed, 2-methoxyphenylpiperazine derivatives are promising candidates to fulfill these criteria. In this study, we aimed...

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Detalhes bibliográficos

Principais autores:	Kinga Sałaciak, Natalia Malikowska-Racia, Klaudia Lustyk, Agata Siwek, Monika Głuch-Lutwin, Grzegorz Kazek, Justyna Popiół, Jacek Sapa, Henryk Marona, Dorota Żelaszczyk, Karolina Pytka
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2021-07-01
coleção:	Pharmaceuticals
Assuntos:	depression 2-methoxyphenylpiperazine forced swim test chronic corticosterone administration 5-HT<sub>1A</sub> receptor D<sub>2</sub> receptor
Acesso em linha:	https://www.mdpi.com/1424-8247/14/8/744
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