Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5

The chemokine receptor CCR5 plays multiple roles in the immune system. Here, structures of Gi1 protein-coupled CCR5 with or without a chemokine bound and of the CCR5- chemokine MIP-1 α complex offer insight into the distinct binding modes of the ligands and into the mechanism of CCR5 activation.

Bibliografiske detaljer

Principais autores:	Hui Zhang, Kun Chen, Qiuxiang Tan, Qiang Shao, Shuo Han, Chenhui Zhang, Cuiying Yi, Xiaojing Chu, Ya Zhu, Yechun Xu, Qiang Zhao, Beili Wu
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2021-07-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-021-24438-5
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!