Palmitic acid activates c-Myc via dual palmitoylation-dependent pathways to promote colon cancer

Abstract c-Myc is broadly hyperactivated in colon cancer, yet the mechanisms sustaining its transcriptional activation remain elusive. Here we identify palmitic acid (PA) as a metabolite cue that activates c-Myc via dual palmitoylation-dependent pathways operating across tumor initiation and progres...

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Detalhes bibliográficos

Principais autores:	Wenxin Du, Jianing Zhang, Yuexin Wang, Minjun Li, Ji Cao, Bo Yang, Qiaojun He, Xuejing Shao, Meidan Ying
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2026-02-01
coleção:	Cell Discovery
Acesso em linha:	https://doi.org/10.1038/s41421-026-00869-6
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