Silencing of Vangl2 attenuates the inflammation promoted by Wnt5a via MAPK and NF-κB pathway in chondrocytes

Abstract Background The Wnt planar cell polarity (PCP) pathway is implicated in osteoarthritis (OA) both in animals and in humans. Van Gogh-like 2 (Vangl2) is a key PCP protein that is required for the orientation and alignment of chondrocytes in the growth plate. However, its functional roles in OA...

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Principais autores:	Ke Zhang, Zhuoying Li, Yunyang Lu, Linyi Xiang, Jiadong Sun, Hong Zhang
格式:	Artigo
语言:	Inglês
出版:	BMC 2021-02-01
丛编:	Journal of Orthopaedic Surgery and Research
主题:	Chondrocytes Osteoarthritis Vangl2 Collagen MMPs Wnt5a/PCP
在线阅读:	https://doi.org/10.1186/s13018-021-02268-x
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