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Yersinia pseudotuberculosis YopE prevents uptake by M cells and instigates M cell extrusion in human ileal enteroid-derived monolayers

Many pathogens use M cells to access the underlying Peyer’s patches and spread to systemic sites via the lymph as demonstrated by ligated loop murine intestinal models. However, the study of interactions between M cells and microbial pathogens has stalled due to the lack of cell culture systems. To...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Alyssa C. Fasciano, Gaya S. Dasanayake, Mary K. Estes, Nicholas C. Zachos, David T. Breault, Ralph R. Isberg, Shumin Tan, Joan Mecsas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis Group 2021-01-01
Schriftenreihe:Gut Microbes
Schlagworte:
m cell
yersinia pseudotuberculosis
human ileal enteroid
polarized epithelial
transcytosis
organoid
cell extrusion
type three secretion system
yope
yoph
Online-Zugang:http://dx.doi.org/10.1080/19490976.2021.1988390
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