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Exploring the Anticancer Properties of 1,2,3-Triazole-Substituted Andrographolide Derivatives

<b>Background/Objectives</b>: The search for new anticancer agents from natural sources remains a key strategy in drug discovery. This study aimed to synthesize and evaluate novel triazole derivatives of the diterpenic lactone andrographolide for their antiproliferative activity against various canc...

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Main Authors: Joana R. L. Ribeiro, Juliana Calheiros, Rita A. M. Silva, Bruno M. F. Gonçalves, Carlos A. M. Afonso, Lucília Saraiva, Maria-José U. Ferreira
Format: Artigo
Language:Inglês
Published: MDPI AG 2025-05-01
Series:Pharmaceuticals
Subjects:
andrographolide
1,2,3-triazole-substituted derivatives
antiproliferative
apoptosis
cell cycle arrest
antimigratory
Online Access:https://www.mdpi.com/1424-8247/18/5/750
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