Mechanism of Ψ-Pro/C-degron recognition by the CRL2FEM1B ubiquitin ligase
Abstract The E3 ligase-degron interaction determines the specificity of the ubiquitin‒proteasome system. We recently discovered that FEM1B, a substrate receptor of Cullin 2-RING ligase (CRL2), recognizes C-degrons containing a C-terminal proline. By solving several cryo-EM structures of CRL2FEM1B bo...
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| Главные авторы: | , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Portfolio
2024-04-01
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| Серии: | Nature Communications |
| Online-ссылка: | https://doi.org/10.1038/s41467-024-47890-5 |
| Метки: |
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