The polymerized protein response (PPR) is activated by genetic variants that polymerize in the ER and is mediated by NFκBp50
Abstract In previous studies we have shown that accumulation of the polymerogenic variant ATZ that causes α1-antitrypsin deficiency (ATD) activates NFκB DNA binding. Here we discovered that this response, which we are naming the polymerized protein response (PPR), is characterized by NFκB p50 homodi...
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| Principais autores: | , , , |
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| 格式: | Artigo |
| 语言: | Inglês |
| 出版: |
Nature Portfolio
2026-04-01
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| 丛编: | Nature Communications |
| 在线阅读: | https://doi.org/10.1038/s41467-026-72369-w |
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