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Nearest neighbor search on embeddings rapidly identifies distant protein relations

Since 1992, all state-of-the-art methods for fast and sensitive identification of evolutionary, structural, and functional relations between proteins (also referred to as “homology detection”) use sequences and sequence-profiles (PSSMs). Protein Language Models (pLMs) generalize sequences, possibly...

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Príomhchruthaitheoirí: Konstantin Schütze, Michael Heinzinger, Martin Steinegger, Burkhard Rost
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Frontiers Media S.A. 2022-11-01
Sraith:Frontiers in Bioinformatics
Ábhair:
Rochtain ar líne:https://www.frontiersin.org/articles/10.3389/fbinf.2022.1033775/full
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