Ubiquitin-specific protease 38 modulates atrial fibrillation susceptibility in chronic kidney disease via STRAP stabilization and activation of TGF-β/SMAD signaling

Abstract Objective This study aimed to elucidate the role of the deubiquitinase USP38 in chronic kidney disease (CKD)-associated atrial fibrillation (AF) by investigating its impact on atrial structural and electrical remodeling and its interaction with STRAP and TGF-β/SMAD signaling. Methods A muri...

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Autors principals:	Hong Meng, Zongze Qu, Zheng Xiao, Bin Kong, Hongjie Yang, Wei Shuai, He Huang
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-06-01
Col·lecció:	Molecular Medicine
Matèries:	Chronic kidney disease Atrial fibrillation USP38 STRAP TGF-β/SMAD signaling
Accés en línia:	https://doi.org/10.1186/s10020-025-01296-1
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