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Pre-mRNA splicing-associated diseases and therapies

Precursor mRNA (pre-mRNA) splicing is an essential step in human gene expression and is carried out by a large macromolecular machine called the spliceosome. Given the spliceosome's role in shaping the cellular transcriptome, it is not surprising that mutations in the splicing machinery can result i...

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Autori principali: Sierra L. Love, Joseph D. Emerson, Kazunori Koide, Aaron A. Hoskins
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis Group 2023-12-01
Serie:RNA Biology
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Accesso online:http://dx.doi.org/10.1080/15476286.2023.2239601
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