Collagen I-induced VCAN/ERK signaling and PARP1/ZEB1-mediated metastasis facilitate OSBPL2 defect to promote colorectal cancer progression

Abstract The global burden of colorectal cancer (CRC) has rapidly increased in recent years. Dysregulated cholesterol homeostasis facilitated by extracellular matrix (ECM) remodeling transforms the tumor microenvironment. Collagen I, a major with ECM component is highly expressed in colorectal tumor...

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Κύριοι συγγραφείς:	Kang Lin, Yun Zhao, Yuqi Tang, Ying Chen, Moubin Lin, Luwei He
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Nature Publishing Group 2024-01-01
Σειρά:	Cell Death and Disease
Διαθέσιμο Online:	https://doi.org/10.1038/s41419-024-06468-1
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