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DrFARM: identification of pleiotropic genetic variants in genome-wide association studies

Abstract In a standard analysis, pleiotropic variants are identified by running separate genome-wide association studies (GWAS) and combining results across traits. But such statistical approach based on marginal summary statistics may lead to spurious results. We propose a new statistical approach,...

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Bibliografische Detailangaben
Hauptverfasser: Lap Sum Chan, Gen Li, Eric B. Fauman, Xianyong Yin, Markku Laakso, Michael Boehnke, Peter X. K. Song
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2025-07-01
Schriftenreihe:Nature Communications
Online-Zugang:https://doi.org/10.1038/s41467-025-60439-4
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