Galectin‐9 alleviates acute graft‐versus‐host disease after haplo‐hematopoietic stem cell transplantation by regulating regulatory T cell/effector T cell imbalance

Abstract Background Acute graft‐versus‐host disease (aGVHD) arises from the imbalance of host T cells. Galectin‐9 negatively regulates CD4 effector T cell (Th1 and Th17) function by binding to Tim‐3. However, the relationship between Galectin‐9/Tim‐3 and CD4+ T subsets in patients with aGVHD after H...

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Autores principales:	Nannan Pang, Shabaaiti Tudahong, Yuejie Zhu, Jiang He, Chunxia Han, Gang Chen, Weiguo Wang, Jing Wang, Jianbing Ding
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Wiley 2024-02-01
Colección:	Immunity, Inflammation and Disease
Materias:	acute graft‐versus‐host disease haplo‐HSCT galectin‐9/Tim‐3 PI3K/AKT/mTOR pathway Treg/Th17 imbalance
Acceso en línea:	https://doi.org/10.1002/iid3.1177
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