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MICA immune complex formed with alpha 3 domain-specific antibody activates human NK cells in a Fc-dependent manner

Abstract Background One of the mechanisms by which tumors evade immune surveillance is through shedding of the major histocompatibility complex (MHC) class I chain-related protein A and B (MICA/B) from their cell surface. MICA/B are ligands for the activating receptor NKG2D on NK and CD8 T cells. Th...

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Detalhes bibliográficos
Principais autores: Changchun Du, Jack Bevers, Ryan Cook, T. Noelle Lombana, Kamalakannan Rajasekaran, Marissa Matsumoto, Christoph Spiess, Jeong M. Kim, Zhengmao Ye
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2019-08-01
coleção:Journal for ImmunoTherapy of Cancer
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Acesso em linha:http://link.springer.com/article/10.1186/s40425-019-0687-9
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