MICA immune complex formed with alpha 3 domain-specific antibody activates human NK cells in a Fc-dependent manner
Abstract Background One of the mechanisms by which tumors evade immune surveillance is through shedding of the major histocompatibility complex (MHC) class I chain-related protein A and B (MICA/B) from their cell surface. MICA/B are ligands for the activating receptor NKG2D on NK and CD8 T cells. Th...
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| Principais autores: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMJ Publishing Group
2019-08-01
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| coleção: | Journal for ImmunoTherapy of Cancer |
| Assuntos: | |
| Acesso em linha: | http://link.springer.com/article/10.1186/s40425-019-0687-9 |
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