Efficacy of the induced pluripotent stem cell derived and engineered CD276-targeted CAR-NK cells against human esophageal squamous cell carcinoma

IntroductionChimeric antigen receptor natural killer (CAR-NK) cells have been found to be successful in treating hematologic malignancies and present potential for usage in solid tumors.MethodsIn this study, we created CD276-targeted CAR-expressing NK cells from pluripotent stem cells (iPSC CD276-ta...

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Detalhes bibliográficos

Principais autores:	Xiaolan Lin, Tian Guan, Yien Xu, Yun Li, Yanchun Lin, Shaobin Chen, Yuping Chen, Xiaolong Wei, Dongsheng Li, Yukun Cui, Yan Lin, Pingnan Sun, Jianmin Guo, Congzhu Li, Jiang Gu, Wei Yang, Haoyu Zeng, Changchun Ma
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2024-03-01
Colecção:	Frontiers in Immunology
Assuntos:	iPSC CD276-targeted CAR-NK patient specific organoid normal control PSO pre-clinical models esophageal squamous cell carcinoma
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1337489/full
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