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Innovation of heterochromatin functions drives rapid evolution of essential ZAD-ZNF genes in Drosophila

Contrary to dogma, evolutionarily young and dynamic genes can encode essential functions. We find that evolutionarily dynamic ZAD-ZNF genes, which encode the most abundant class of insect transcription factors, are more likely to encode essential functions in Drosophila melanogaster than ancient, co...

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Autori principali: Bhavatharini Kasinathan, Serafin U Colmenares III, Hannah McConnell, Janet M Young, Gary H Karpen, Harmit S Malik
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications Ltd 2020-11-01
Serie:eLife
Soggetti:
heterochromatin
positive selection
gene turnover
krab-zinc finger
gene essentiality
chromatin
Accesso online:https://elifesciences.org/articles/63368
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