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Silent agonists for α7 nicotinic acetylcholine receptors

We discuss models for the activation and desensitization of α7 nicotinic acetylcholine receptors (nAChRs) and the effects of efficacious type II positive allosteric modulators (PAMs) that destabilize α7 desensitized states. Type II PAMs such as PNU-120596 can be used to distinguish inactive compound...

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Principais autores: Roger L. Papke, Marta Quadri, Alican Gulsevin
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-04-01
Serier:Pharmacological Research
Fag:
Nicotinic acetylcholine receptor
Inflammation
Signal transduction
Desensitization
Allosteric modulation
Online adgang:http://www.sciencedirect.com/science/article/pii/S1043661823000920
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