Nicotinic acetylcholine receptor agonist attenuates ILC2-dependent airway hyperreactivity
Airway hyperreactivity is driven by type 2 cytokines produced by ILC2 and Th2 cells. Here the authors show that an α7-nicotinic receptor agonist (GTS-21) inhibits ILC2 responses and is therapeutic against Alternaria-induced airway hyperreactivity in a humanized mouse model.
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| Principais autores: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2016-10-01
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| coleção: | Nature Communications |
| Acesso em linha: | https://doi.org/10.1038/ncomms13202 |
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