Immune activation following PD-L1 inhibitor plus chemoradiotherapy in locally advanced rectal cancer: a retrospective, single-arm study

BackgroundLocally advanced rectal cancer (LARC) is challenging due to high recurrence rates and poor responses to neoadjuvant chemoradiotherapy (nCRT). Combining nCRT with immunotherapy may enhance antitumor immunity by modifying the tumor microenvironment (TME). This study evaluates the efficacy of...

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Hlavní autoři:	Shaoqing Fan, Zeming Zhao, Qingyu Meng, Haiqian Wang, Bin Yu, Wenbo Niu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-08-01
Edice:	Frontiers in Immunology
Témata:	locally advanced rectal cancer neoadjuvant chemoradiotherapy tumor microenvironment PD-L1 inhibitor tumor-infiltrating lymphocytes
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1619043/full
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