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Mitotic Exit Function of Polo-like Kinase Cdc5 Is Dependent on Sequential Activation by Cdk1

To complete mitosis, Saccharomyces cerevisiae needs to activate the mitotic phosphatase Cdc14. Two pathways contribute to Cdc14 regulation: FEAR (Cdc14 early anaphase release) and MEN (mitotic exit network). Cdc5 polo-like kinase was found to be an important mitotic exit component. However, its spec...

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Principais autores: Jose-Antonio Rodriguez-Rodriguez, Yolanda Moyano, Soraya Játiva, Ethel Queralt
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2016-05-01
Series:Cell Reports
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Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2211124716305241
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