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Acetate Improves the Killing of Streptococcus pneumoniae by Alveolar Macrophages via NLRP3 Inflammasome and Glycolysis-HIF-1α Axis

Short-chain fatty acids (SCFAs) are metabolites produced mainly by the gut microbiota with a known role in immune regulation. Acetate, the major SCFA, is described to disseminate to distal organs such as lungs where it can arm sentinel cells, including alveolar macrophages, to fight against bacteria...

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Autori principali: Marina Gomes Machado, Thiago Andrade Patente, Yves Rouillé, Severine Heumel, Eliza Mathias Melo, Lucie Deruyter, Benoit Pourcet, Valentin Sencio, Mauro Martins Teixeira, François Trottein
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2022-01-01
Serie:Frontiers in Immunology
Soggetti:
alveolar macrophages
short chain fatty acid
immunometabolism
Streptococcus pneumoniae
innate immunity
nitric oxide
Accesso online:https://www.frontiersin.org/articles/10.3389/fimmu.2022.773261/full
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