Loss of Anti-Tumor Efficacy by Polyamine Blocking Therapy in GCN2 Null Mice

GCN2 is one of the main sensors of amino acid starvation stress, and its activation in the stressful tumor microenvironment plays a crucial role in tumor survival and progression. We hypothesized that elevated polyamine biosynthesis and subsequent depletion of precursor arginine activates GCN2, thus...

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Autors principals:	Eric T. Alexander, Erin Fahey, Otto Phanstiel, Susan K. Gilmour
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2023-10-01
Col·lecció:	Biomedicines
Matèries:	polyamine blocking therapy GCN2 α-difluoromethylornithine transport inhibitor macrophages myeloid derived suppressor cells
Accés en línia:	https://www.mdpi.com/2227-9059/11/10/2703
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