Addressing the challenges of immunogenicity, heterogeneity and tumorigenicity in the clinical translation of human embryonic stem cells

Abstract The clinical translation of human embryonic stem cells (hESCs) presents promising potential for regenerative medicine, offering innovative treatments for a diverse array of conditions including neurodegenerative diseases, spinal cord injuries, diabetes, and heart disease. This review articl...

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Hauptverfasser:	Lishuang Xia, Jia Qin, Sheng Ye
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-11-01
Schriftenreihe:	Stem Cell Research & Therapy
Schlagworte:	Human Embryonic Stem Cells (hESCs) Immunogenicity Tumorigenicity Heterogeneity HLA modification Advanced gene editing
Online-Zugang:	https://doi.org/10.1186/s13287-025-04826-0
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