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In vitro, in vivo, and in silico approaches for evaluating the preclinical DMPK profiles of ammoxetine, a novel chiral serotonin and norepinephrine reuptake inhibitor

Background and AimAmmoxetine, a novel chiral serotonin and norepinephrine reuptake inhibitor, holds promise for major depressive disorder treatment. This study aimed to thoroughly investigate its preclinical drug metabolism and pharmacokinetics (DMPK) profiles.MethodsThe preclinical DMPK profiles of...

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Huvudupphov: Xiuqing Zhu, Yuexin Li, Huan Luo, Yunxia Zhang, Zhenqing Zhang, Jinglai Li
Materialtyp: Artigo
Språk:Inglês
Utgiven: Frontiers Media S.A. 2024-11-01
Serie:Frontiers in Pharmacology
Ämnen:
ammoxetine
depression
antidepressant
serotonin and norepinephrine reuptake inhibitor
drug metabolism and pharmacokinetics
ADME
Länkar:https://www.frontiersin.org/articles/10.3389/fphar.2024.1486856/full
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