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Bioengineering of rFVIIa Biopharmaceutical and Structure Characterization for Biosimilarity Assessment

Eptacog alfa (NovoSeven®) is a vitamin K-dependent recombinant Factor VIIa produced by genetic engineering from baby hamster kidney (BHK) cells as a single peptide chain of 406 residues. After activation, it consists of a light chain (LC) of 152 amino and a heavy chain (HC) of 254 amino acids. Recom...

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Principais autores: Othman Montacir, Houda Montacir, Murat Eravci, Andreas Springer, Stephan Hinderlich, Fereidoun Mahboudi, Amirhossein Saadati, Maria Kristina Parr
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2018-01-01
Colecção:Bioengineering
Assuntos:
biopharmaceutical
biosimilar
mass spectrometry
physicochemical characterization
coagulation assay
Acesso em linha:http://www.mdpi.com/2306-5354/5/1/7
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