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MERVL/Zscan4 Network Activation Results in Transient Genome-wide DNA Demethylation of mESCs

Mouse embryonic stem cells are dynamic and heterogeneous. For example, rare cells cycle through a state characterized by decondensed chromatin and expression of transcripts, including the Zscan4 cluster and MERVL endogenous retrovirus, which are usually restricted to preimplantation embryos. Here, w...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Mélanie A. Eckersley-Maslin, Valentine Svensson, Christel Krueger, Thomas M. Stubbs, Pascal Giehr, Felix Krueger, Ricardo J. Miragaia, Charalampos Kyriakopoulos, Rebecca V. Berrens, Inês Milagre, Jörn Walter, Sarah A. Teichmann, Wolf Reik
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2016-09-01
Schriftenreihe:Cell Reports
Schlagworte:
Zscan4
MERVL
endogenous retrovirus
embryonic stem cell
DNA methylation
imprint
preimplantation
reprogramming
chromatin
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2211124716311962
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