Can small drugs predict the intrinsic aqueous solubility of ‘beyond Rule of 5’ big drugs?
The aim of the study was to explore to what extent small molecules (mostly from the Rule of 5 chemical space) can be used to predict the intrinsic aqueous solubility, S0, of big molecules from beyond the Rule of 5 (bRo5) space. It was demonstrated that the General Solubility Equation (GSE) and the A...
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| Principais autores: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
International Association of Physical Chemists (IAPC)
2020-04-01
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| coleção: | ADMET and DMPK |
| Acesso em linha: | https://pub.iapchem.org/ojs/index.php/admet/article/view/794 |
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