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Global and Conditional Disruption of the <i>Igf-I</i> Gene in Osteoblasts and/or Chondrocytes Unveils Epiphyseal and Metaphyseal Bone-Specific Effects of IGF-I in Bone

To evaluate the relative importance of IGF-I expression in various cell types for endochondral ossification, we quantified the trabecular bone at the secondary spongiosa and epiphysis of the distal femur in 8–12-week-old male mice with a global knockout of the <i>Igf-I</i> gene, as well as the condi...

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Principais autores: Weirong Xing, Chandrasekhar Kesavan, Sheila Pourteymoor, Subburaman Mohan
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2023-09-01
Series:Biology
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Acceso en liña:https://www.mdpi.com/2079-7737/12/9/1228
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