Selective loss and transcriptional reprogramming of Nox4+ GABAergic neurons in the trigeminal nucleus caudalis of NTG-induced chronic migraine model

Abstract Background Chronic migraine is a disabling neurological disorder with complex mechanisms. The trigeminal nucleus caudalis (TNC) is a critical relay in migraine pathogenesis, yet its cellular and molecular underpinnings remain unclear. Methods We applied single-nucleus RNA sequencing (snRNA-...

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Principais autores:	Yunhao Xu, Yiping Deng, Peiyu Wu, Mengke Tian, Chen Liu, Xuyang Liu, Danhua Liu, Yinan Guo, Pengfei Wang, Yuming Xu, Yonggang Wang, Yusheng Li
格式:	Artigo
語言:	Inglês
出版:	BMC 2025-11-01
叢編:	The Journal of Headache and Pain
主題:	Chronic migraine TNC GABAergic neurons Nox4 snRNA-seq
在線閱讀:	https://doi.org/10.1186/s10194-025-02203-z
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