ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling
Upon membrane depolarization, the KCNQ1 potassium channel opens at the intermediate (IO) and activated (AO) states of the stepwise voltage-sensing domain (VSD) activation. In the heart, KCNQ1 associates with KCNE1 subunits to form IKs channels that regulate heart rhythm. KCNE1 suppresses the IO stat...
Na minha lista:
| Principais autores: | , , , , |
|---|---|
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
eLife Sciences Publications Ltd
2019-07-01
|
| 叢編: | eLife |
| 主題: | |
| 在線閱讀: | https://elifesciences.org/articles/48576 |
| 標簽: |
沒有標簽, 成為第一個標記此記錄!
|