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Hexavalent chromium inhalation exposure induces metabolic reprogramming underlying lung injury and partial endogenous repair in mice

Hexavalent chromium [Cr(VI)] is a pervasive toxicant in occupational and environmental settings, posing significant respiratory risks, yet the metabolic mechanisms underpinning its pulmonary toxicity and repair remain unclear. In this study, C57BL/6 J mice underwent 28 days of whole‑body inhalation...

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Main Authors: Changmao Long, Yuexuan Wang, Yeting Peng, Guiping Hu, Baojun Zhang, Li Su, Tian Chen, Guang Jia
Format: Artigo
Language:Inglês
Published: Elsevier 2026-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Hexavalent chromium
Inhalation exposure
Lung injury
Metabolomics
Eicosanoids
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651326000813
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