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PNPLA3 and TM6SF2 exacerbate the impact of alcohol and metabolic dysfunction on liver fibrosis

Background & Aims: Genetic predisposition (especially variants in PNPLA3 and TM6SF2), metabolic dysfunction, and alcohol consumption are established risk factors for steatotic liver disease (SLD) and progression of fibrosis. However, the clinical relevance of their interaction and its implicatio...

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Principais autores: Sophie Gensluckner, Helle Lindholm Schnefeld, Jan Embacher, Camilla Dalby Hansen, Lorenz Balcar, Katrine Tholstrup Bech, Paul Thöne, Nikolaj Torp, Bernhard Wernly, Laura Maarit Pikkupeura, Stephan Zandanell, Christian Datz, Michael Strasser, Mads Israelsen, Mattias Mandorfer, Torben Hansen, Aleksander Krag, Elmar Aigner, Maja Thiele, Georg Semmler
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2026-01-01
Colecção:JHEP Reports
Assuntos:
PNPLA3
TM6SF2
Liver fibrosis
Steatotic liver disease
Alcohol
Metabolic dysfunction
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2589555925003313
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