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In vitro evaluation of new terpenoid derivatives against Leishmania infantum and Leishmania braziliensis

The activity of five (1-5) abietane phenol derivatives against Leishmania infantum and Leishmania braziliensis was studied using promastigotes and axenic and intracellular amastigotes. Infectivity and cytotoxicity tests were performed with J774.2 macrophage cells using Glucantime as a reference drug...

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Principais autores: Inmaculada Ramírez-Macías, Clotilde Marín, Rachid Chahboun, Francisco Olmo, Ibtisam Messouri, Oscar Huertas, María Jose Rosales, Ramón Gutierrez-Sánchez, Enrique Alvarez-Manzaneda, Manuel Sánchez-Moreno
Formato: Artigo
Idioma:Inglês
Publicado em: Fundação Oswaldo Cruz (FIOCRUZ) 2012-05-01
coleção:Memorias do Instituto Oswaldo Cruz
Assuntos:
abietane phenol compounds
Leishmania infantum
Leishmania braziliensis
biological evaluation of activity
promastigote
amastigote forms
Acesso em linha:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000300012&lng=en&tlng=en
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